Highly enantioselective hydroamination to six-membered rings by heterobimetallic catalysts.
نویسندگان
چکیده
New bimetallic Zn/Zr salen-type systems were employed as catalysts in the asymmetric intramolecular hydroamination reaction. High enantioselectivity for the formation of piperidines of up to 98% ee were observed.
منابع مشابه
Zirconium-catalyzed desymmetrization of aminodialkenes and aminodialkynes through enantioselective hydroamination.
The catalytic addition of alkenes and amines (hydroamination) typically provides α- or β-amino stereocenters directly through C-N or C-H bond formation. Alternatively, desymmetrization reactions of symmetrical aminodialkenes or aminodialkynes provide access to stereogenic centers with the position controlled by the substrate's structure. In the present study of an enantioselective zirconium-cat...
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 29 شماره
صفحات -
تاریخ انتشار 2014